Product Overview:
HIV-1 Gag p17 is the matrix protein of AIDS virus HIV-1 and is produced by the digestion of its precursor Gag p55 by HIV-1 protease. This protein is indispensable to the reproduction of AIDS virus and constitutes an essential element for the of AIDS virus particle construction. The product is prepared by immunizing rabbit with recombinant p17 protein which was over-expressed in E. coli with a plasmid carrying the Gag p17 coding region of HIV-1 virus, subtype B, and highly purified by several steps of chromatography. Using this antiserum in Western blotting, the bands of 17 kD and 55 kD corresponding respectively to HIV-p17 and to its precursor p55 were observed in the extract of the AIDS virus infected cells.