DNA (cytosine-5) methyltransferase ...

DNA (cytosine-5) methyltransferase 1 (Dnmt1), Active

As One International, Inc.

Product Information

Product Overview:

DNA methylation is significant for epigenetic regulation of gene expression, X chromosome inactivation, genomic imprinting, and development. Abberant methylation patterns are associated with certain human tumors and developmental abnormalities. In vertebrates, there are two types of DNA methyltransferase activities; de novo and maintenance types. Two DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the creation of methylation patterns at an early stage of embryogenesis (de novo-type), while Dnmt1 is responsible for the maintenance of methylation patterns during replication. Dnmt1 favors to methylate the hemimethylated DNA and preferentially methylates one strand of the double-stranded DNA during its processive methylation.
This product, mouse Dnmt1 deleting the N-terminal 290 amino acid residues, was expressed using a baculovirus expression system and purified by Prof. S. Tajima and Dr. I. Suetake of Osaka University (ref.2).

1) In vitro metylation of cytosine residues in hemimethylated DNA at 5’….CG…3’. (ref. 1,2)
2) Antigen for anti-mammalian Dnmt1 antibodies.

Catalog#: 10-201
LID#: 3045P
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Order by Phone or Fax: 1.800.316.3081
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Raised InE. coli
Unit Size300 units
Safety StatementsThis product is for research use only.
Sample AvailabilityNo

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Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No


Storage Temperature: See datasheet

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