Anti-CDT2 antibody, rabbit polyclon...

Anti-CDT2 antibody, rabbit polyclonal

As One International, Inc.

Product Information

Product Overview:

CDT2 (human, 730 aa, 79.5 kDa) is substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. CDT2 is activated by checkpoint kinase ATR following DNA damage. Reactive against human and mouse Cdt2 proteins. Not tested with other species.

    Applications
  1. Western blotting (1/2,000 dilution).
  2. Immunoprecipitation (1/100~1/200 dilution)
  3. Immunofluorescence staining (1/100~1/1,000)
  4. FACS (assay dependent).
  5. Other applications have not been tested.

Application:

WB, IP, IF, FACS

Catalog#: 70-115
LID#: 3910A
Quantity :
Order by Phone or Fax: 1.800.316.3081
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Specifications

ClonalityPolyclonal
Raised InRabbit
ReactivityHuman, mouse
Gene IDQ9NZJ0
Unit Size100 ug
Safety StatementsThis product is for research use only.
Sample AvailabilityNo

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: See datasheet

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