Rheb Antibody

Rheb Antibody

Product Information

Product Overview:

Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demon-strate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.

Catalog#: H00006009-D01
LID#: 171696A
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Specifications

Host SpeciesRabbit
SpeciesHuman
Entrez Human ID6009
NotesThis product is produced by and distributed for Abnova, a company based in Taiwan.
PreservationNo Preservative
Species ReactivityThis product is reactive against Human.
Swissprot Human IDNP_005605.1
Gene SymbolRHEB
ApplicationsWB, ELISA, IP
Species AbbreviationHu
Grade/PurityWhole antisera
ClonalityPolyclonal
ImmunogenRHEB (NP_005605.1, 1 a.a. ~ 184 a.a) full-length human protein.MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
Storage BufferPBS [pH 7.2]
DilutionWestern Blot , ELISA, Immunoprecipitation
Gene ID6822
Unit Size0.1ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymGTP-binding protein Rheb, MGC111559, Ras homolog enriched in brainRHEB2Ras homolog enriched in brain 2

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

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