Retinoic Acid Receptor beta Antibod...

Retinoic Acid Receptor beta Antibody (336)

Product Information

Product Overview:

Retinoids can reverse various premalignant lesions as well as prevent some second primary tumors. The effects of retinoids are regulated by retinoic acid receptors (RAR) and retinoid X receptors, which act as ligand-activated transcription factors. Ligand-dependent transcriptional activation of RARs is a multistep process that ends with the formation of a multimeric co-activator complex on regulated promoters (1,2). Loss of RAR-beta expression and the accumulation of p53 and Ki67 proteins may help in the early identification of esophageal cancer in high-risk populations (3).

Application:

By Western blot analysis a ~48 kDa band can be seen using rat brain hippocampal homogenate. WB was tested in TBST (20 mM Tris/HCl (7.6), 137 mM NaCl, 1% Tween-20) containing 5% nonfat milk and 0.05% NaN3.

Catalog#: NB200-323
LID#: 171528A
Quantity :
Order by Phone or Fax: 1.800.316.3081

Specifications

Host SpeciesMouse
SpeciesHuman, Rat
Entrez Human ID5915
PreservationNo Preservative
Species ReactivityTested in Human. Rat reactivity reported in scientific literature (PMID: 18272600). Reactivity assumed based on 100% sequence identity: Canine, Guinea Pig, Mouse and Rat.
Swissprot Human IDP10826
Gene SymbolRARB
ApplicationsWB, ICC/IF, IHC, IHC-Fr, IHC-P
Species AbbreviationHu, Rt
Grade/PurityImmunogen affinity purified
Clone336
ClonalityMonoclonal
ImmunogenSynthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH
SpecificitySpecific for the ~48k RAR-beta isotype.
IsotypeIgG1
Storage Buffer10 mM Hepes (pH7.5), 150 mM NaCl, 100 ug/ml BSA and 50% glycerol
DilutionWestern Blot 1:1000, Immunohistochemistry-Paraffin 1:10-1:2000, Immunohistochemistry-Frozen 1:10-1:2000, Immunocytochemistry/Immunofluorescence 1:10-1:2000, Immunohistochemistry 1:10-1:2000
Gene ID10318
Unit Size0.05mg
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
Synonymbeta polypeptide, HBV-activated protein, retinoic acid receptor, beta

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at -20C. Avoid freeze-thaw cycles.

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