Moesin Antibody

Moesin Antibody

Product Information

Product Overview:

Moesin (membrane-organizing extension spike protein) has previously been characterized as a possible receptor protein for heparan sulfate and also as a cytoskeletal linker protein that stabilizes cell surface microvilli, filopodia and lamellipodia. Data indicate that moesin is identical to the 77-kDa band that copurifies with ezrin in its isolation from human placenta (1). Members of the ezrin-radixin-moesin (ERM) family of membrane-cytoskeletal linking proteins have NH2- and COOH-terminal domains that associate with the plasma membrane and the actin cytoskeleton, respectively (2). It has been demonstrated that ezrin-radixin-moesin proteins are rapidly inactivated after antigen recognition through a Vav1-Rac1 pathway. The resulting disanchoring of the cortical actin cytoskeleton from the plasma membrane decreased cellular rigidity, leading to more efficient T cell-antigen-presenting cell conjugate formation (3).

Application:

This antibody is useful in ELISA, Western Blot and Immunohistochemistry-Paraffin.

Catalog#: 22750002
LID#: 171579A
Quantity :
Order by Phone or Fax: 1.800.316.3081

Specifications

Host SpeciesRabbit
SpeciesHuman
Entrez Human ID4478
NotesManufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs.
PreservationNo Preservative
Species ReactivityHuman.
Swissprot Human IDP26038
Gene SymbolMSN
ApplicationsWB, ELISA, IHC, IHC-P
Species AbbreviationHu
Grade/PurityAffinity purified
ClonalityPolyclonal
ImmunogenThis antibody is specific for the C Terminus Region of the target protein.
SpecificityThis product is specific for Human MSN.
Storage Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
DilutionELISA 1:100-1:2000, Western Blot 1:5000-1:20000, Immunohistochemistry-Paraffin 1:250-1:2000, Immunohistochemistry 1:10-1:2000
Gene ID10623
Unit Size0.05mg
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymMembrane-organizing extension spike protein, moesin

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at -20C. Avoid freeze-thaw cycles.

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