Maxi Potassium channel alpha Antibo...

Maxi Potassium channel alpha Antibody

Product Information

Product Overview:

Function: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel also contains binding sites for Ca(2+) and Mg(2+).; Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD). Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both.; Enzyme regulation: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation.; Subcellular location: Membrane, Multi-pass membrane protein.; Tissue specificity: Widely expressed. Except in myocytes, it is almost ubiquitously expressed.

Catalog#: NBP1-20161
LID#: 171785A
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Specifications

Host SpeciesRabbit
SpeciesHuman
Entrez Human ID3778
PreservationNo Preservative
Species ReactivityHuman. Predicted cross-reactivity based on sequence identity: Mouse (95%), Rat (95%).
Swissprot Human IDQ12791
Gene SymbolKCNMA1
ApplicationsWB, IHC, IHC-Fr, IHC-P
Species AbbreviationHu
Grade/PurityWhole antisera
ClonalityPolyclonal
ImmunogenA synthetic peptide 4th cytoplasmic domain of human Potassium channel subfamily M subunit alpha 1 (KCNMA1, KCa1.1, SLO) conjugated to an immunogenic carrier protein was used as the immunogen.
Storage BufferLyophilized whole serum.
DilutionImmunohistochemistry 1:300-1:2000, Immunohistochemistry-Frozen 1:300-1:2000, Immunohistochemistry-Paraffin 1:300-1:2000, Western Blot 1:300-1:2000
Gene ID22920
Unit Size0.1ml
ConcentrationLYOPH
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymbA205K10.1, BK channel, BKCA alpha, BKCA alpha subunit, BKTM, calcium-activated potassium channel subunit alpha-1, DKFZp686K1437, hSlo, KCNMA, K(VCA)alpha, k(VCA)alpha, Maxi K channel, MaxiK, MGC71881, potassium large conductance calcium-activated channel, subfamily M, alphamember 1, SAKCA, Slowpoke homolog, Slo homolog, SLO1, Slo1, Slo-alpha, SLO-ALPHA, stretch-activated Kca channel, subfamily M subunit alpha-1

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

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