MST2 Antibody

MST2 Antibody

Product Information

Product Overview:

Mammalian Sterile 20-Like 2 (Mst2) is most similar to the previously identified Mst1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. An in-vitro kinase assay indicates that Mst2 can phosphorylate an exogenous substrate, as well as itself, and phospho-amino-acid analysis indicates that it is a serine/threonine protein kinase (1) Mst2, a STE20-family member and purported Hpo ortholog, phosphorylates and activates both Lats1 and Lats2. Results indicate that Mst2-like kinases regulate Lats kinase activities in an evolutionarily conserved regulatory pathway (2). When stably expressed in HeLa cells, Mst highly sensitizes the cells to death receptor-mediated apoptosis by accelerating caspase-3 activation. These findings suggest that Mst1 and Mst2 play a role in apoptosis both upstream and downstream of caspase activation (3).

Catalog#: NBP1-32313
LID#: 171836A
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Specifications

Host SpeciesRabbit
SpeciesHuman
Entrez Human ID6788
LocalizationCytoplasm, Nucleus
Preservation0.01% Thimerosal
Species ReactivityTested in human. Not yet tested in any other species.
Gene SymbolSTK3
ApplicationsWB, ICC/IF, IHC, IHC-P
Species AbbreviationHu
Grade/PurityAffinity purified
ClonalityPolyclonal
ImmunogenRecombinant fragment corresponding to a region within amino acids 1 and 269 of STK3 (Uniprot ID#Q13188)
Storage Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7.0).
DilutionImmunocytochemistry/Immunofluorescence 1:10-1:2000, Immunohistochemistry-Paraffin 1:10-1:2000, Western Blot 1:500-1:3000, Immunohistochemistry 1:10-1:2000
Gene ID5583
Unit Size0.1ml
Concentration0.84 mg/ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymEC 2.7.11, FLJ90748, KRS1, Mammalian STE20-like protein kinase 2, MST-2, MST2EC 2.7.11.1, serine/threonine kinase 3, serine/threonine kinase 3 (STE20 homolog, yeast), serine/threonine kinase 3 (Ste20, yeast homolog), serine/threonine-protein kinase 3, Serine/threonine-protein kinase Krs-1, STE20-like kinase MST2

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at -20C. Avoid freeze-thaw cycles.

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