MC4 Receptor Antibody

MC4 Receptor Antibody

Product Information

Product Overview:

MC4 receptor is the fourth member of the five known melanocortin receptors (MCRs) belonging to the rhodopsin-like family of G protein-coupled receptors (GPCRs). These five MCRs form a unique family of GPCRs, marked by their unusually short coding sequence and the absence of highly conserved amino acid residues or motifs common to most GPCRs. All MCRs signal through the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. With the exception of MC2R, all MCRs are activated by both adrenocorticotropin (ACTH) and melanocyte-stimulating hormones (MSHs and mainly alpha-MSH). The MC4R receptor is expressed primarily in the brain, and unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. Genetic studies of mice and humans have established a critical role of MC4 Receptor in appetite regulation. Heterozygous mutations in MC4 Receptor account for 1-6% of severe cases of human obesity.

Catalog#: NBP1-71102-0.1mg
LID#: 171523A
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Host SpeciesRabbit
SpeciesHuman, Mouse, Rat
Entrez Human ID4160
Preservation0.02% Sodium Azide
Species ReactivityHuman,Mouse, Rat
Swissprot Human IDP32245
Gene SymbolMC4R
ApplicationsWB, ELISA
Species AbbreviationHu, Mu, Rt
Grade/PurityImmunogen affinity purified
ImmunogenThe antiserum was produced against synthesized peptide derived from human MC4R. The immunogen region is: C-terminal.
SpecificityMC4R Antibody detects endogenous levels of total MC4R protein.
Storage Bufferphosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 268% glycerol.
DilutionELISA 1:40000, Western Blot 1:500-1:1000
Unit Size0.1mg
Concentration1 mg/ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymMC4-R, melanocortin receptor 4, melanocortin 4 receptor, MGC138197, MGC126851

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Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No


Storage Temperature: Store at -20C. Avoid freeze-thaw cycles.

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