MBD1 Antibody

MBD1 Antibody

Product Information

Product Overview:

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21. [provided by RefSeq]

Catalog#: NBP2-17234
LID#: 171792A
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Specifications

Host SpeciesRabbit
SpeciesHuman
Entrez Human ID4152
LocalizationNucleus speckle
Preservation0.01% Thimerosal
Species ReactivityHuman.
Swissprot Human IDQ9UIS9
TMW55 kDa
Gene SymbolMBD1
ApplicationsWB
Species AbbreviationHu
Grade/PurityImmunogen affinity purified
ClonalityPolyclonal
ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 106 and 355 (Q9UIS9) of MBD1
Storage Buffer1XPBS, 1%BSA, 20% Glycerol (pH7).
DilutionWestern Blot 1:500-1:3000
Unit Size0.1ml
Concentration1 mg/ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymCXXC-type zinc finger protein 3, methyl-CpG binding domain protein 1, methyl-CpG binding domain protein 1 isoform PCM1, methyl-CpG-binding domain protein 1, Methyl-CpG-binding protein MBD1, PCM1CXXC3RFT, Protein containing methyl-CpG-binding domain 1, the regulator of fibroblast growth factor 2 (FGF-2) transcription

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at -20C. Avoid freeze-thaw cycles.

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