MBD1 Antibody (4F6)

MBD1 Antibody (4F6)

Product Information

Product Overview:

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21. [provided by RefSeq]

Application:

Antibody reactive against cell lysate and recombinant protein for Western Blot. GST tag alone is used as a negative control. Has also been used for ELISA

Catalog#: H00004152-M03
LID#: 171793A
Quantity :
Order by Phone or Fax: 1.800.316.3081

Specifications

Host SpeciesMouse
SpeciesHuman
Entrez Human ID4152
NotesThis product is produced by and distributed for Abnova, a company based in Taiwan.
PreservationNo Preservative
Species ReactivityHuman.
Swissprot Human IDNP_056671
Gene SymbolMBD1
ApplicationsWB, ELISA, S-ELISA
Species AbbreviationHu
Grade/PurityIgG purified
Clone4F6
ClonalityMonoclonal
ImmunogenMBD1 (NP_056671, 415 a.a. ~ 509 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.HHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTDLVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDE
SpecificityMBD1 - methyl-CpG binding domain protein 1 (4F6)
IsotypeIgG2b Kappa
Storage BufferIn 1x PBS, pH 7.2
DilutionSandwich ELISA, Western Blot 1:500, ELISA
Gene ID90865
Unit Size0.1mg
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymCXXC-type zinc finger protein 3, methyl-CpG binding domain protein 1, methyl-CpG binding domain protein 1 isoform PCM1, methyl-CpG-binding domain protein 1, Methyl-CpG-binding protein MBD1, PCM1CXXC3RFT, Protein containing methyl-CpG-binding domain 1, the regulator of fibroblast growth factor 2 (FGF-2) transcription

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

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