MASPIN Antibody

MASPIN Antibody

Product Information

Product Overview:

MASPIN (mammary serine protease inhibitor; SERPINB5 or PI5), is a member of SERPIN superfamily (serine protease inhibitor/non-inhibitor) which also includes certain other proteins such as plasminogen activator inhibitors 1/2 and alpha1-antitrypsin. MASPIN is an extracellular matrix tumor supressor which blocks the proliferative, invasive, and metastatic properties of breast as well as prostate cancers. Because it does not undergo S (stressed) to R (relaxed) conformational transition characteristic of active SERPINS, MASPIN does not exhibit serine protease inhibitory activity. MASPIN expression is down-regulated in breast, prostate, gastric and melanoma cancers, however, this protein is overexpressed in certain other malignancies such as pancreatic, gallbladder, colorectal, and thyroid cancers which reflects that MASPIN may play different activities in different cell types. These observations may be explained by MASPIN's distinct subcellular localization - cytoplasmic, nuclear or both cytoplasmic-nuclear expression; by interactions with extracellular matrix; its structure and epigenetic modifications. MASPIN is also expressed in corneal epithelial tissue, wherein it controls the migration/adhesion of corneal stromal fibroblasts and myofibroblasts during corneal wound healing.

Application:

This MASPIN antibody is useful for Western blot, where a doublet is seen at ~40 kDa. Does not work in Immunocytochemistry/Immunofluorescence.

Catalog#: NB110-97377SS
LID#: 171636A
Quantity :
Order by Phone or Fax: 1.800.316.3081
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Specifications

Host SpeciesRabbit
SpeciesHuman
ControlsAntigen standard for SERPINB5 (NM_002639) (transient overexpression lysate), HeLa Whole Cell Extract
Entrez Human ID5268
LocalizationSecreted, extracellular space.
Preservation0.1% Sodium Azide
Species ReactivityHuman.
Swissprot Human IDP36952
TMW40 kDa
Gene SymbolSERPINB5
ApplicationsWB, ICC/IF (-)
Species AbbreviationHu
Grade/PurityImmunogen affinity purified
ClonalityPolyclonal
ImmunogenSynthetic peptide made to an internal portion of human MASPIN (within residues 100-200). [Swiss-Prot# P36952]
Storage BufferPBS, 30% glycerol
DilutionICC/IF (Negative), Western Blot 0.5 ug/ml
Gene ID29114
Unit Size0.025ml
Concentration1 mg/ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
Synonymmaspin, Maspin, Peptidase inhibitor 5, PI-5, PI5protease inhibitor 5 (maspin), serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5, serpin peptidase inhibitor, clade B (ovalbumin), member 5, serpin B5

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

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