Lass5 Antibody

Lass5 Antibody

Product Information

Product Overview:

The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis. Multiple isoforms of LASS5 are known to exist. This antibody may cross-react with the highly homologous LASS6.

Application:

LASS5 antibody can be used for detection of LASS5 by Western blot at 1 - 2 mg/ml.

Catalog#: NBP1-77328
LID#: 171550A
Quantity :
Order by Phone or Fax: 1.800.316.3081

Specifications

Host SpeciesRabbit
SpeciesHuman, Mouse, Rat
Entrez Human ID91012
Preservation0.02% Sodium Azide
Species ReactivityHuman, Mouse, Rat
Swissprot Human IDNP_671723
Gene SymbolCERS5
ApplicationsWB, ELISA, ICC/IF
Species AbbreviationHu, Mu, Rt
Grade/PurityAffinity purified
ClonalityPolyclonal
ImmunogenAntibody was raised against a 17 amino acid peptide near the carboxy terminus of the human LASS5.
Storage BufferPBS
DilutionELISA 1:100-1:2000, Immunocytochemistry/Immunofluorescence 1:10-1:2000, Western Blot 1:100-1:2000
Unit Size0.1mg
Concentration1 mg/ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymCerS5, FLJ25304, LAG1 homolog, ceramide synthase 5, LAG1 longevity assurance homolog 5, LAG1 longevity assurance homolog 5 (S. cerevisiae), MGC45411, Trh4

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

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