L-DOPA Antibody

L-DOPA Antibody

Product Information

Product Overview:

L Dopa is an intermediate in dopamine biosynthesis. Clinically, L Dopa is used in the management of Parkinson's disease. It is used as a prodrug to increase dopamine levels since it is able to cross the blood-brain barrier whereas dopamine itself cannot. Once L Dopa has entered the central nervous system (CNS), it is metabolised to dopamine by aromatic L amino acid decarboxylase. This also occurs in the peripheral tissues, causing adverse effects and decreasing the available dopamine to the CNS, so it is standard practice to co administer a peripheral DOPA decarboxylase inhibitor and often a catechol-O-methyl transferase (COMT) inhibitor. The antiserum was tested using the free floating PAP technique on rat dopaminergic areas. The anti-conjugated L-DOPA antibodies gave a good staining between 1/2000-1/5000 dilution in these areas.

Catalog#: NB100-65501
LID#: 171762A
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Specifications

Host SpeciesRabbit
SpeciesAll Species
Preservation0.09% Sodium Azide
Species ReactivityReacts with Broad.
ApplicationsELISA
Species AbbreviationAll
Grade/PurityIgG purified
ClonalityPolyclonal
ImmunogenSynthetic L-Dopa conjugated to BSA via glutaraldehyde
SpecificityNB100-65501 is specific for conjugated L-dihydroxyphenylalanine (L-DOPA). The following reactivites were determined by competition ELISA: L-Dopa-G-BSA (1), alpha-methyl-L-Dopa-G-BSA (1/2,200), 3-O-methyl-L-Dopa-G-BSA (1/50,000), Dopamine-G-BSA (>1/50,000), Noradrenaline-G-BSA (>1/50,000), Tyrosine-G-BSA (>1/50,000). *L-Dopa-G-BSA concentration/other conjugated catecholamine concentration at half displacement.L-Dopa is an amino acid that is converted to dopamine in the brain. It is often given to patients in order to alleviate some of the symptoms of Parkinson's disease as, unlike dopamine itself, it can cross the blood-brain barrier.
Storage BufferPhosphate buffered saline, pH 7.2
DilutionELISA 1:5000-1:10000
Gene ID5241
Unit Size0.05ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
Synonym3 4 dihydroxy L phenylalanine, L dihydroxyphenylalanine, Levodopa

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

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