Influenza A Virus M2 Antibody (14C2...

Influenza A Virus M2 Antibody (14C2)

Product Information

Product Overview:

Influenza A virus is an enveloped virus encoding 10 polypeptides. RNA segment 7 encodes for two proteins: M1 (matrix 1) and M2 (matrix 2). M1 protein is encoded by an mRNA that is colinear, while M2 protein is synthesized from spliced mRNA. M2 protein is a transmembrane protein composed of three Domains: 1) 24 residues representing the N-terminal region, 2) 19 hydro-phobic residues that serve as a membrane anchor, and 3) 54 residues near the C-terminal in the cytoplasmic domain. The M2 protein has been found to play a role in Influenza replication and assembly of virion particles. Further experimentation has demonstrated that this protein is an acid-activated ion channel for virus replication.

Application:

By Western blot, this antibody detects a ~15 kDa protein representing the M2 protein. It has demonstrated the ability to restrict the replication of some strains of influenza A virus by binding to the extracellular N-Terminal domain. Although not tested this antibody may work in Immunohistochemistry. Blocking reported in literature (PMID: 7571410).

Catalog#: NB100-2073
LID#: 171736A
Quantity :
Order by Phone or Fax: 1.800.316.3081

Specifications

Host SpeciesMouse
SpeciesHuman, Virus, Xenopus
Preservation0.05% Sodium Azide
Species ReactivityVirus.
ApplicationsWB, B/N, FLOW, ICC/IF, IP
Species AbbreviationHu, Vi, Xp
Grade/PurityProtein G purified
Clone14C2
ClonalityMonoclonal
ImmunogenThe M2 protein from A/WSN/33-infected CV1 cell lysate.
IsotypeIgG1 Kappa
Storage BufferPBS, 1mg/ml BSA
DilutionBlocking/Neutralizing, Flow Cytometry 1:10-1:1000, Immunocytochemistry/Immunofluorescence 1 ug/ml, Immunoprecipitation 10 ug/ml, Western Blot 1 ug/ml
Gene ID130507
Unit Size0.1mg
Concentration1.0 mg/ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at -20C. Avoid freeze-thaw cycles.

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