Indian Hedgehog Antibody (EP1192Y)

Indian Hedgehog Antibody (EP1192Y)

Product Information

Product Overview:

Hedgehog, WNT, FGF and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors, such as gastric cancer and pancreatic cancer (1). The hedgehog family of morphogens are regulators of cell proliferation, differentiation and cell-cell communication. These morphogens have been shown to have important roles in organogenesis, spermatogenesis, stem cell maintenance and oncogenesis. Indian hedgehog (IHH) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone (2). It has been shown that IHH, synthesized by prehypertrophic and hypertrophic chondrocytes, regulates the site of hypertrophic differentiation by signaling to the periarticular growth plate and also determines the site of bone collar formation in the adjacent perichondrium. By providing crucial local signals from prehypertrophic and hypertrophic chondrocytes to both chondrocytes and preosteoblasts, IHH couples chondrogenesis to osteogenesis in endochondral bone development (3).

Application:

This product is useful for: Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation. In Western blot this antibody detects a band at approximately 45kDa.

Catalog#: NB110-57122
LID#: 171643A
Quantity :
Order by Phone or Fax: 1.800.316.3081

Specifications

Host SpeciesRabbit
SpeciesHuman, Mouse, Rat
Entrez Human ID3549
NotesManufactured incorporating RabMAb® technology under Epitomics US patents, No 5675,063 and 7,429,487, owned by Abcam.
Preservation0.01% Sodium Azide
Species ReactivityReacts with: Mouse, Rat, Human
Swissprot Human IDQ14623
TMW45 kDa
Gene SymbolIHH
ApplicationsWB, IHC, IHC-P, IP
Species AbbreviationHu, Mu, Rt
Grade/PurityTissue culture supernatant
CloneEP1192Y
ClonalityMonoclonal
ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human IHH was used as an immunogen.
IsotypeIgG
Storage BufferPBS 49%, Glycerol 50%, BSA 0.05%
DilutionImmunohistochemistry 1:10-1:2000, Immunohistochemistry-Paraffin 1:250-500, Immunoprecipitation 1:30, Western Blot 1:1000
Unit Size0.1 ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymBDA1Indian hedgehog homolog (Drosophila), HHG2, HHG-2, Indian hedgehog, Indian hedgehog (Drosophila) homolog, Indian hedgehog homolog, indian hedgehog protein

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at -20C. Avoid freeze-thaw cycles.

Customer Reviews

Average Customer Rating
(0)
Review & Rating Distribution

Customers Who Viewed This Item Also Viewed

Novus Biologicals
Novus Biologicals
Novus Biologicals
Novus Biologicals