IRAK2 Antibody

IRAK2 Antibody

Product Information

Product Overview:

The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappaB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappaB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappaB activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. Unlike human IRAK2, murine IRAK2 exists as four alternately spliced isoforms (IRAK2a-d), with two isoforms (IRAK2c and d) acting in an inhibitory fashion. IRAK2 is expressed in a variety of tissues.

Application:

IRAK2 antibody can be used for detection of mouse IRAK2 by Western blot at 0.5 - 1 mg/ml. Anti-IRAK2 has no cross response to IRAK.

Catalog#: NBP1-76424
LID#: 171742A
Quantity :
Order by Phone or Fax: 1.800.316.3081

Specifications

Host SpeciesRabbit
SpeciesMouse
Entrez Human ID3656
Preservation0.02% Sodium Azide
Species ReactivityMouse
Gene SymbolIRAK2
ApplicationsWB, ELISA
Species AbbreviationMu
Grade/PurityAffinity purified
ClonalityPolyclonal
ImmunogenAntibody was raised against a peptide corresponding to 16 amino acids near the carboxy-terminus of mouse IRAK2a which is common to all four isoforms.
Storage BufferPBS
DilutionELISA 1:100-1:2000, Western Blot 1:100-1:2000
Unit Size0.1mg
Concentration1 mg/ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
Synonyminterleukin-1 receptor associated kinase-2, IRAK-2, interleukin-1 receptor-associated kinase 2, interleukin-1 receptor-associated kinase-like 2, MGC150550

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

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