IRAK2 Antibody (6C7)

IRAK2 Antibody (6C7)

Product Information

Product Overview:

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2 (1). Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kB activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kB activation (2,3).Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.

Application:

Antibody reactive against cell lysate and recombinant protein for Western Blot. Has also been used for immunohistochemistry (paraffin) and ELISA.

Catalog#: H00003656-M01
LID#: 171757A
Quantity :
Order by Phone or Fax: 1.800.316.3081

Specifications

Host SpeciesMouse
SpeciesHuman
Entrez Human ID3656
NotesThis product is produced by and distributed for Abnova, a company based in Taiwan.
PreservationNo Preservative
Species ReactivityHuman. Other species not tested.
Swissprot Human IDNP_001561
Gene SymbolIRAK2
ApplicationsWB, ELISA, IHC, IHC-P
Species AbbreviationHu
Grade/PurityIgG purified
Clone6C7
ClonalityMonoclonal
ImmunogenIRAK2 (NP_001561, 111 a.a. ~ 210 a.a) partial recombinant protein with GST tag.KPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPA FLQPPEEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGD SLFWSEADVVQATDDF
SpecificityIRAK2 - interleukin-1 receptor-associated kinase 2
IsotypeIgG1 Kappa
Storage BufferPhosphate buffered saline, pH 7.2
DilutionELISA, Western Blot 1:500, Immunohistochemistry-Paraffin, Immunohistochemistry
Gene ID93627
Unit Size0.05mg
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
Synonyminterleukin-1 receptor associated kinase-2, interleukin-1 receptor-associated kinase 2, IRAK-2, interleukin-1 receptor-associated kinase-like 2, MGC150550

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

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