IMPDH2 Antibody

IMPDH2 Antibody

Product Information

Product Overview:

IMPDH, inosine monophosphate dehydrogenase, has been demonstrated to mediate negative regulation of Toll-like receptor 2 activity via the NF-kB signaling pathway (1). IMPDH upregulates phosphatase activity of SHP-1 which then goes on to inactivate PI3-k. The central function of IMPDH in the regulation of guanosine nucleotide pathways- conversion of IMP- inosine monophosphate to XMP-xanthosine monophosphate is a critical controlling step in de novo synthesis of guanosine nucleotides in T and B lymphocytes affecting proliferation (2). Because of this, IMPDH specific detection and control has made it a target for immunosuppressive, anti-cancer, anti-parasitic, or anti-viral therapy (3). Monitoring IMPDH or IMPDH2 activity as a biomarker for mycophenolic acid-induced immunosuppression in renal transplants is one such use of IMPDH or IMPDH2 specific probes (4).

Catalog#: NBP2-27195
LID#: 171590A
Quantity :
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Specifications

Host SpeciesRabbit
SpeciesHuman, Mouse, Rat, Amphibian, Bovine, Canine, Chicken, Chinese Hamster, Equine, Guinea Pig, Primate, Opossum, Other, Porcine, Rabbit
Entrez Human ID3615
Preservation0.05% Sodium Azide
Species ReactivityThe amino acid sequence used as immunogen for this antibody is 100% homologous in human, mouse, rat, sumatran orangutan, white-cheeked gibbon, rhesus monkey, new world monkey, panda, cow, guinea pig, dog, chinese hamster, zebrafish, horse, chicken, african bush elephant, wild turkey, opossum, platypus, cichlid fish, rabbit, chimpanzee, salmon, pig, zebra finch, and frog.This antibody will detect both IMPDH1 and IMPDH2 in test samples. Additionally, there are multiple isoforms of the IMPDH protein. Researchers are encouraged to use a tool such as NCBI BLAST to determine theoretical sizes of, and cross reaction with, the various isoforms.
Swissprot Human IDP12268
Gene SymbolIMPDH2
ApplicationsWB, IHC, IHC-P
Species AbbreviationHu, Mu, Rt, Am, Bv, Ca, Ch, ChHa, Eq, GP, Mk, Op, Other, Po, Rb
Grade/PurityProtein A purified
ClonalityPolyclonal
ImmunogenAmino acids 221-238 IIARTDLkkNRDYPLASk from human IMPDH was used as the immunogen for this antibody.
Storage Buffer0.1 mg antibody in 0.2 ml PBS containing 0.05% BSA .
DilutionImmunohistochemistry 5ug/ml, Immunohistochemistry-Paraffin, Western Blot 2-4ug/ml~
Unit Size0.1mg
Concentration0.5 mg/ml
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymEC 1.1.1.205, IMP (inosine 5'-monophosphate) dehydrogenase 2, IMP (inosine monophosphate) dehydrogenase 2, IMP dehydrogenase 2, IMPD 2, IMPD2IMP oxireductase 2, IMPDH 2, IMPDH-II, inosine 5' phosphate dehydrogenase 2, inosine monophosphate dehydrogenase type II, inosine-5'-monophosphate dehydrogenase 2

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

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