Bacillus Anthracis Lethal Factor An...

Bacillus Anthracis Lethal Factor Antigen Antibody (LFA27)

Product Information

Product Overview:

The protease enzyme Lethal Factor (LF) is one of the three proteins (LF, EF & PA) composing the anthrax toxin produced by Bacillus anthracis, a bacteria which can infect many mammalian species and that may be fatal. LF is not toxic by itself, but when associated with Protective Antigen (PA), can then gain entry to cells. Once inside the cell, LF then cleaves the N terminal of most dual specificity mitogen activated protein kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N terminal proline rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LF intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.

Application:

Best recommended pairs (capture-detection): NB100-73104 - NB100-73105

Catalog#: NB100-73105
LID#: 171802A
Quantity :
Order by Phone or Fax: 1.800.316.3081
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Specifications

Host SpeciesMouse
SpeciesBacteria
Preservation0.1% Sodium Azide
Species ReactivityBacteria.
ApplicationsS-ELISA
Species AbbreviationBa
Grade/PurityProtein G purified
CloneLFA27
ClonalityMonoclonal
Immunogenhighly purified lethal factor antigen of Bacillus anthracis.
SpecificityBacillus anthracis lethal factor.
IsotypeIgG2a
Storage BufferPBS, pH 7.4
DilutionSandwich ELISA 1:100-1:2000
Gene ID266727
Unit Size0.2mg
Safety StatementsThis product is for research use only and is not approved for use in humans or in clinical diagnosis.
Sample AvailabilityYes
SynonymAnthrax lethal toxin endopeptidase component, Anthrax lethal toxin endopeptidase component, Anthrax LF, Anthrax LF, Anthrax lethal factor, Anthrax lethal factor, B.anthracis lethal factor, B.anthracis lethal factor, bacillus anthracis lethal factor, bacillus anthracis lethal factor, Lef, Lef, LF, LF

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: Store at 4C. Do not freeze.

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