anti-prion antibody(clone 2C5-5)

anti-prion antibody(clone 2C5-5)

As One International, Inc.

Product Information

Product Overview:

Prion protein PrP is a membrane glycosylphosphatidylinositol(GPI) anchored glycoprotein highly expressed in neurons and glial cells, as well as immune and reproductive cells. Mutations, mostly in the octapeptide repeat regions, have been associated with neurodegenerative diseases such as Creutzfeldt Jakob disease, fatal familial insomnia, Gerstmann Straussler disease, Huntington disease like 1, and kuru. The infectious isoform of PrPC, known as PrPSc, is able to induce a conformational change in normal PrPC proteins to convert them into the infectious isoform.    Both forms of PrP are initially expressed as a ~250 amino acid protein which is truncated to produce the mature protein of 209 amino acids. Several topological forms exist: one cell surface form which is anchored via a glycolipid modification, and two transmembrane forms. Thus, more than one band is visible on an SDS-PAGE.    The mouse monoclonal 2C5-5 recognizes human and mouse prions. Other species have not been tested. The antibody was produced using recombinant human PrP lacking GPI anchor expressed and purified from rabbit kidney cell line RK13 by K. Ikuta’s laboratory at Osaka University.

Application:

WB, ELISA

Catalog#: 65-901
LID#: 3159A
Quantity :
Order by Phone or Fax: 1.800.316.3081
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Specifications

ClonalityMonoclonal
Raised InRabbit
ReactivityHuman
Gene IDP04156
Unit Size50 ug
Safety StatementsThis product is for research use only.
Sample AvailabilityNo

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: See datasheet

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