Cortisone Chemiluminescent CLIA kit

Cortisone Chemiluminescent CLIA kit

As One International, Inc.

Product Information

Product Overview:

The B-Bridge Cortisone Chemiluminescent Immunoassay kit is designed to quantitatively measure Cortisone present in samples. A cortisone standard is provided to generate a standard curve for the assay. After a two hour incubation the plate is washed and the chemiluminescent substrate is added. The substrate reacts with the bound cortisone-peroxidase conjugate to produce light. The generated light is detected in a multilabel microtiter plate reader.

Cortisone and cortisol concentrations vary due to the activity of two 11 Beta-hydroxysteroid dehydrogenases (11-HSD). While most tissues have the ability to express either enzyme, 11 Beta-HSD1 is found primarily in the liver where it converts cortisone to cortisol while 11 Beta-HSD2 is found in tissues such as the kidney where cortisol receptor binding is required. 11 Beta-HSD2 deactivates cortisol to cortisone, prohibiting receptor activation. This glucocorticoid “shuttle” helps to initiate and regulate the anti-inflammatory response. Monitoring the ratio of cortisone:cortisol has applications in diabetes, obesity, metabolic syndrome, osteoporosis, and chronic fatigue syndrome in addition to adrenal diseases. Cortisone and cortisol concentrations exhibit a predictable diurnal pattern and can be measured in extracted dried feces, or in serum, plasma, saliva and urine. A recent publication has suggested that salivary cortisone is a good surrogate marker for serum cortisol.

Catalog#: K3017-5
LID#: 3289I
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Order by Phone or Fax: 1.800.316.3081
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Specifications

ReactivitySpecies Independent
Unit Size5 x 96 rxns
Safety StatementsThis product is for research use only.
Sample AvailabilityNo

Shipping & Handling

Estimated Ship Time: 3 Business Days

Shipped In: Blue Ice

Hazardous Material: No

Storage

Storage Temperature: See datasheet

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